Three-Parent Babies… Or Are They?
Keywords:
Health, Biology, Genetics, IVFAbstract
Considering the topic of 3-parent IVF, this paper aims to determine how much DNA, in terms of base pairs of nucleotides, is actually contributed by the notorious ‘third parent’. By considering how much DNA is contained in the nucleus and mitochondria of an average cell, the percentage contributed by each parent to the recipient child is found to be 0.27% from the third parent, and 49.9% from each of the two conventional parents. An alternative calculation is also presented, using only the coding DNA region, however this is rationalised to be a less appropriate model.
References
MitoAction (n.d.), About Mitochondrial Disease [Homepage of MitoAction], [Online] Available: http://www.mitoaction.org/mito-faq [Accessed 01/03/015].
J. Gallagher (2015-last) MP's say yes to three-person babies, Homepage of BBC, [Online] Available: http://www.bbc.co.uk/news/health-31069173 [Accessed 03/03/2015].
NHGRI (2010) The Human Genome Project Completion: Frequently Asked Questions, Homepage of National Human Genome Research Institute, [Online] Available: http://www.genome.gov/11006943 [Accessed 04/03/2015].
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2008) Molecular Biology of the Cell. 5th edn. New York: Garland Science.
GHR (2015), Mitochondrial DNA, Homepage of Genetics Home Reference, [Online] Available: http://ghr.nlm.nih.gov/chromosome/MT [Accessed 05/03/2015].
Yu, J., Yang, Z., Kibukawa, M., Paddock, M., Passey, D.A. & Wong, G. (2002) Minimal Introns Are Not “Junk”, Genome Research, 12, 1185-1189. Available: http://genome.cshlp.org/content/10/11/1672.long [Accessed 05/03/2015].
de Roos, A (2015). A eukaryotic origin of mitochondria, [Online] Available: http://www.origin-of-mitochondria.net/ [Accessed 18/02/2015].
Nott, A., Meislin, S. & Moore, M. (2003) A quantitative analysis of intron effects on mammalian gene expression, http://rnajournal.cshlp.org/content/9/5/607.long RNA Society. [Accessed 05/03/2015].
Baylis, F. (2013) The ethics of creating children with three genetic parents. Reproductive biomedicine online, 26(6), pp.531–4. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23608245 [Accessed 31/01/2015].
Downloads
How to Cite
Issue
Section
License
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. All content is licensed under a Creative Commons Attribution 4.0 International licence (CC-BY 4.0).